The attack started in the ultra-orthodox city of Bnei Brak, just east of Tel Aviv, before continuing on and ending near the entrance to Ramat Gan.
A police spokesperson said a preliminary investigation found that at least one assailant used an assault rifle against civilians in several locations before being killed by local police forces. It is not clear whether one of the dead was an assailant.
Among the five dead was a police officer who engaged with the attacker, police said in a statement.
Bnei Brak Mayor Avraham Rubinstein pleaded with residents to stay indoors in the hours after the shooting, telling Israeli Channel 12 people should wait for instructions from police as officers cased the area in case of more assailants.
The attack came the day after foreign ministers from four Arab countries met with their Israeli counterpart and the US Secretary of State in the southern kibbutz…